Duloxetine Side Effects, Overdose and Pregnancy Information

Duloxetine side effects include nausea, vomiting , constipation, diarrhea, and decreased sex drive. Other Duloxetine side effects may include sweating, fatigue, insomnia, dizziness, headache, anxiety, nervousness, agitation, drowsiness, tremor, blurred vision, dry mouth, decreased appetite, weight loss cold hands or feet, and itching.

Duloxetine Side Effects Reporting

If you experience any Duloxetine side effects not mentioned above you should report it to your primary health care provider or FDA 1-800-FDA-1088 in the United States, Health Canada 1-866-225-0709 in Canada, MHRA 020 3080 6000 in UK, or TGA 1800 020 653 in Australia.

Duloxetine is a type of drug known as combined serotonin and noradrenaline reuptake inhibitor (Serotonin and noradrenaline are compounds called neurotransmitters). Duloxetine is used to treat depression and generalized anxiety disorder, pain and tingling caused by diabetic neuropathy, fibromyalgia, moderate to severe stress urinary incontinence (SUI) in women. SUI is the accidental leakage of urine when pressure in the bladder is increased suddenly such as by coughing, sneezing, laughing, lifting or exercise.

Duloxetine Warning and Caution

Duloxetine is also used as an antidepressant (Brand name Cymbalta). As with other antidepressant drugs, there have been reported cases of people experiencing suicidal thoughts during or shortly after stopping treatment with Duloxetine. For this reason, inform your physician right away if you have any suicidal, distressing thoughts or feelings, including depressive feelings or agitation, at any time while taking Duloxetine or even after stopping treatment.

Duloxetine may cause drowsiness and may reduce the ability to drive or operate machinery.

Duloxetine may cause a sudden drop in blood pressure when moving from a lying or sitting position to sitting or standing position, which may cause dizziness, light-headedness or fainting.

In some individuals Duloxetine may cause blood pressure to increase.

Duloxetine may cause restlessness often accompanied by an inability to sit or stand still.

Duloxetine should not be stopped abruptly as this may cause withdrawal symptoms such as dizziness, needles sensations, nausea, difficulty sleeping, intense dreams, headache, tremor, agitation or anxiety. Withdrawal symptoms are temporary and are not the same as addiction. They can usually be avoided by stopping Duloxetine gradually, over at least two weeks.

Duloxetine should be used with caution in Seniors, people with decreased kidney or liver functions, manic depression, history of mania, seizures, glaucoma, high blood pressure, heart disease, and those taking anticoagulant drugs.

Duloxetine should not be given to children 18 and under.

People who have taken a monoamine oxidase inhibitor (MAOI) antidepressant medicine in the last 14 days.

People taking the drugs fluvoxamine, ciprofloxacin or enoxacin.

Rare hereditary problems of fructose intolerance.

Duloxetine and Pregnancy

Duloxetine should not be used during pregnancy. Seek medical advice from your physician if you get pregnant or plan to get pregnant while using Duloxetine. Duloxetine passes into breast milk. Nursing mothers should switch to bottle-feed while taking Duloxetine.

Duloxetine Interaction

The following drugs may increase the blood level of Duloxetine and should not be given in combination with Duloxetine:

Ciprofloxacin

Enoxacin

Fluvoxamine.

Duloxetine must not be taken at the same time as, or within 14 days of taking a monoamine oxidase inhibitor (MAOI) antidepressant.

Duloxetine must not be combines with the following:

SSRI antidepressants

Tricyclic antidepressants

Venlafaxine

Tryptophan

Tramadol

Triptans for Migraine

Herb St John's wort

Antipsychotics

Narcotic painkillers

Benzodiazepines

Barbiturates

Sedating antihistamines

Sleeping pills

Anticoagulants (water pills)

Antiplatelet drugs such as Aspirin

Non-steroidal anti-inflammatory drugs (NSAIDs) e.g. Acetaminophen(Paracetamol), ibuprofen.

Duloxetine may increase the blood levels of the following drugs:

Flecainide

Metoprolol

Propafenone

Risperidone

Tricyclic antidepressants

Duloxetine Overdose

Duloxetine overdose symptoms include nausea, vomiting, confusion, dizziness, and other heightened side effects symptoms. In case of Duloxetine overdose, seek medical attention right away.

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