Zactran: Veterinary drug
Zactran is used in cattle to treat or to prevent Bovine Respiratory Disease (BRD) caused by the bacteria
Mannheimia haemolytica, Pasteurella multocida and
Histophilus somni. When using Zactran to prevent BRD the presence of the disease in the herd should be established first. Zactran is given as a single subcutaneous (under the skin) injection. The dose to use is calculated based on the weight of the animal being treated. Animals weighing more than 550 lbs.(250 kg) will need to be injected at more than one site. Zactran works by blocking the bacteria's ribosomes, which are the parts of the cells where proteins are produced, and consequently inhibiting the growth of bacteria. Zactran has been shown to be efficacious in the treatment and prevention of BRD, associated with
Mannheimia haemolytica, Pasteurella multocida and
Histophilus somni. In the treatment of BRD Zactran has been shown to be as effective as tulathromycin. Main ingredient in Zactran solution for injection for cattle contains the antibiotic Gamithromycin (150 mg/ml).
ZACTRAN SIDE EFFECTS
After injection of Zactran, up to 45% of animals will show some swelling at the site of injection. The animals may also show some signs of slight pain for one day. The swelling generally resolves in 3 to 14 days but may persist in some animals for up to 35 days after treatment.
Zactran: Precautions for Humans
People with known hypersensitivity (allergy) to similar antibiotics (macrolide class) should avoid contact with Zactran. Zactran may cause irritation to the eyes or the skin. Therefore, contact with skin or eyes should be avoided. If Zactran comes in direct contact with the eyes, they should be flushed immediately with clean water.
Similarly, if Zactran comes into direct contact with skin the affected area should be washed immediately with clean water. In case of accidental self-injection, medical advice should be sought immediately and the package leaflet or the label should be presented to the physician.
Zactran: Withdrawal Period
After the last administration of Zactran, cattle should not be slaughtered for 64 days.
Zactran: Milk Consumption
As the safety of Zactran in breeding animals has not been studied, the drug should not be used in lactating cows or heifers producing milk for human consumption. Zactran should also not be used in pregnant cows or heifers which are intended to produce milk for human consumption within 2 months of calving.
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