Bupropion Side Effects, Overdose and Pregnancy Information

Bupropion, a fairly new antidepressant medication, is used to treat severe depression when all other drugs have been ineffective, primarily because of high risk of seizures. Bupropion is also given to stop smoking habit. Bupropion takes about 2-4 weeks to function properly.

Bupropion Side Effects

Bupropion side effects may include upset stomach, agitation, anxiety, dizziness, constipation, dry mouth, headache, appetite loss, nausea, vomiting, excessive sweating, rash, insomnia, and tremor. Rare Bupropion side effects may include severe allergic reactions, breathing difficulty, chest pain, impotence, urinary problems, confusion, sedation, fatigue, fever, euphoria, menstrual complaints, chills, delusions, suicidal thoughts, and weight gain or loss.

Bupropion Side Effects Reporting

If you experience any Bupropion side effects not mentioned above you should report it to your primary health care provider or FDA 1-800-FDA-1088 in the United States, Health Canada 1-866-225-0709 in Canada, MHRA 020 3080 6000 in UK, or TGA 1800 020 653 in Australia.

BUPROPION CAUTION

Those who have had seizures in the past, head injury or were diagnosed with eating disorders should discuss this with their physician before using Bupropion.

If you have had any kind of heart, or liver or kidney disease, be sure to discuss this with your physician before starting Bupropion. A lower dose may be needed.

About 25 percent of people who take Bupropion experience appetite loss and weight loss of about 5 lbs or more.
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Do not take Bupropion within the past two weeks of taking a monoamine oxidase inhibitor (MAO inhibitor) drug. This could result in a sudden and unsafe rise in blood pressure.

BUPROPION INTERACTIONS

Avoid alcohol while taking Bupropion; an interaction between them may enhance the possibility of a seizure.

Check with your doctor before combining Bupropion with the following:
Beta-blockers
Blood thinning drugs
Carbamazepine
Cimetidine
Cyclophosphamide
Levodopa
Major tranquilizers
MAO inhibitors
Nicotine patches
Orphenadrine
Other antidepressants
Phenobarbital
Phenytoin
Steroids
Theophylline

BUPROPION AND PREGNANCY

If you are or planning to become pregnant, inform your physician right away. The safety of taking Bupropion during pregnancy is not well established.

Nursing mothers should switch to bottle-feed while taking Bupropion.

BUPROPION DOSES

CHILDREN
Not recommended for children under 18.
ADULTS
Depression:
100-450 mg/day; divided into 3-4 doses. Not to exceed 450 mg in a 24-hour period.
Smoking Cessation
150 mg twice daily. Not to exceed 300 mg in a 24-hour period.

BUPROPION OVERDOSE

Symptoms of Bupropion overdose may include hallucinations, loss of consciousness, seizures, angina, nausea, vomiting and breathing problems. If you suspect Bupropion overdose, seek medical help right away.
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